2. Cardiovascular Disease

Cardiovascular Disease

Cardiovascular Disease

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Cardiovascular diseases (CVDs) are the leading causes of death and disability worldwide. CVDs include diseases of the heart, vascular diseases of the brain and diseases of blood vessels. Caused by atherosclerosis, coronary heart disease and cerebrovascular disease are the most common forms of CVDs. Other less common forms of CVDs include rheumatic heart disease and congenital heart disease. A large percentage of CVDs is preventable through the reduction of behavioral risk factors such as tobacco use, physical inactivity and unhealthy diet. Dietary sodium reduction can alleviate the long-term risk of cardiovascular disease events. Statin therapy is an effective intervention in both the primary and secondary preventions of CVDs in those who are at high risk.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-120442
    (±)16(17)-DiHDPA 1345275-27-5 98%
    (±)16(17)-DiHDPA is a epoxygenase metabolite of docosahexaenoic acid (HY-B2167). (±)16(17)-DiHDPA inhibits platelet aggregation at concentrations below those affecting thromboxane synthesis.
    (±)16(17)-DiHDPA
  • HY-120514
    JNc-440 1119503-63-7
    JNc-440 is a potent antihypertensive agent. JNc-440 can enhance the interaction of TRPV4 and Ca2+-activated potassium channel 3 (KCa2.3) in endothelial cells. JNc-440 can also enhance vasodilation, and exerted antihypertensive effects in mice.
    JNc-440
  • HY-120980
    Thromboxane B1 64626-32-0 98%
    Thromboxane B1 (TXB1) is one of thromboxane B (TXB) family members. Thromboxane is a member of the family of lipids known as eicosanoids. Thromboxane is named for its role in blood clot formation (thrombosis).
    Thromboxane B1
  • HY-121018
    Daltroban 79094-20-5 98.1%
    Daltroban (BM-13505) is a selective and specific thromboxane A2 (TXA2) receptor antagonist. Daltroban increase intracellular calcium in vascular smooth muscle cells. Daltroban shows protective effect in reperfusion injury.
    Daltroban
  • HY-121287
    Ioxynil 1689-83-4 ≥98.0%
    Ioxynil is an herbicide that act as endocrine disruptor. Ioxynil can disrupt vascular and heart development in zebrafish.
    Ioxynil
  • HY-121385
    Hydroxy bosentan 253688-60-7 ≥98.0%
    Hydroxy bosentan (Ro 48-5033) is a primary metabolite of Bosentan (BOS) metabolized by the cytochrome P450 system in the liver. Ro 48-5033 assists BOS pharmacologically, retaining 10%-20% activities.
    Hydroxy bosentan
  • HY-122235
    MRL-24 393794-17-7 99.58%
    MRL-24 is a PPARγ agonist. MRL-24 can be used in metabolic disease related research.
    MRL-24
  • HY-122439
    Lovastatin acid 75225-51-3 98%
    Lovastatin acid (Mevinolinic acid), an active metabolite of Lovastatin, is a potent competitive HMG-CoA reductase inhibitor with a Ki of 0.6 nM.
    Lovastatin acid
  • HY-122543
    PPACK II diTFA 649748-23-2
    PPACK II diTFA is an irreversible and specific glandular and plasma kallikreins inhibitor.
    PPACK II diTFA
  • HY-123179
    Mefruside 7195-27-9 ≥99.0%
    Mefruside is an orally active diuretic and has a mild hypotensive effect. Mefruside inhibits the synthesis of urea in an isolated rat liver perfusion model. Mefruside can be used in studies of oedema and hypertension.
    Mefruside
  • HY-123349
    5α-Hydroxy-6-keto cholesterol 13027-33-3 ≥99.0%
    5α-Hydroxy-6-keto cholesterol is major metabolite of β-epoxide (5α,6β-epoxycholesterol) during direct exposure of intact cultured human bronchial epithelial cells (16-HBE) to ozone. 5α-Hydroxy-6-keto cholesterol inhibits cholesterol synthesis with an IC50 of 350 nM.
    5α-Hydroxy-6-keto cholesterol
  • HY-123669
    R-138727 204204-73-9 98%
    R-138727, the thiol-containing active metabolite of Prasugrel, is an irreversible platelet P2Y12 receptor inhibitor. R-138727 inhibits ADP-induced platelet aggregation.
    R-138727
  • HY-123825
    GX-674 1432913-36-4
    GX-674 is a potent, state-dependent, isoform-selective voltage-gated sodium channel 1.7 (Nav1.7) antagonist with an IC50 of 0.1 nM at -40 mV.
    GX-674
  • HY-123927
    UniPR1331 1809170-59-9
    UniPR1331 is a 3β-hydroxy-Δ5-choline acid derivative that inhibits Eph-ephrin interactions. UniPR1331 interacts with VEGFR2 and blocks the interaction of VEGFR2 with its natural ligand vascular endothelial growth factor and subsequent autophosphorylation, signaling, and pro-angiogenic activation of endothelial cells in vitro. UniPR1331 also inhibits tumor cell-driven angiogenesis in zebrafish.
    UniPR1331
  • HY-123983
    HS56 922050-57-5 99.6%
    HS56 is an ATP-competitive dual Pim/DAPK3 inhibitor with Ki values of 0.26, 0.208, 2.94, and ＞100 μM for DAPK3, Pim-3, Pim-1, and Pim-2, respectively. HS56 inhibits LC20 phosphorylation and smooth muscle contraction. HS56 decreases blood pressure in spontaneously hypertensive mice. HS56 can be used in research of hypertension.
    HS56
  • HY-125095
    Yonkenafil hydrochloride 804519-64-0 99.43%
    Yonkenafil (Tunodafil) hydrochloride, a novel phosphodiesterase 5 (PDE5) inhibitor, is effective in reducing cerebral infarction, neurological deficits, edema, and neuronal damage in the infarcted area. Yonkenafil (Tunodafil) hydrochloride may improve cognitive function by modulating neurogenesis and has a potential therapeutic effect on Alzheimer's disease.
    Yonkenafil hydrochloride
  • HY-125108
    PHPS1 sodium 1177131-02-0 ≥98.0%
    PHPS1 sodium is a potent and selective Shp2 inhibitor with Kis of 0.73, 5.8, 10.7, 5.8, and 0.47 μM for Shp2, Shp2-R362K, Shp1, PTP1B, and PTP1B-Q, respectively.
    PHPS1 sodium
  • HY-125139
    omega-3 Arachidonic acid ethyl ester, in ethanol, 98% 123940-93-2 ≥98.0%
    omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.
    omega-3 Arachidonic acid ethyl ester, in ethanol, 98%
  • HY-125748
    CBM-301940 902146-11-6 99.4%
    CBM-301940 (compound 5) is an orally active malonate CoA decarboxylase (MCD) inhibitor with IC50 value of 23 nM. CBM-301940 can be used in the study of cardiovascular diseases.
    CBM-301940
  • HY-125780
    5-Phenylhydantoin 89-24-7
    5-Phenylhydantoin is an antiepileptic compound, and has certain hypolipidemic compound.
    5-Phenylhydantoin
Cat. No. Product Name / Synonyms Application Reactivity